번역샘플 - 한영 번역

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VI. Gliding Joint or Arthrodia
Because the joint is formed by the opposing, plane surfaces of epiphyses, one articular surface’s gliding motion is restricted to a limited range on the other surface. Hence, it is the joint with the most limited motion among all the diarthrodial joints, which is found at carpal, ankle and sacroiliac joints.
A synarthrosis is divided into a fibrous joint (syndesmosis) and a cartilaginous joint.

1. Fibrous Joint
   There are 2 types of fibrous joints: sutures, wherein the articular surfaces of two bones interlock like gears to form a joint  as in the cranium; and synchondrosis, wherein a cartilaginous plate comes between epiphyses allowing no mobility as in the joint between occipital and sphenoid bones.
2. Cartilaginous Joint
   Cartilaginous Joints are capable of a slight degree of movement and have 2 types: symphyses, which are found at the joints between the vertebral bodies, between the pubic bones and between the manubrium and the body of sternum; and syndesmoses, which are located at the joint between the styloid process and hyoid bone, and at the lower joint between the tibia and fibula.

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감수자–오역: 원본은 관절이 “제한된 범위내의 미끄러지는 정도의 운동밖에 할 수 없다” 감수자–가독성: 가독성을 위해 수정 감수자–오역: 원본은 평면관절이 수근관절, 족근관절, 천장관절에서 볼 수 있다는 뜻이지 모든 가동관절을 말하는 것이 아님

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원어민 에디터-명료성: 문맥상의 명료함을 위해 관절명을 추가 원어민 에디터-단어선택: 문법상의 명료성을 위해 “plane”으로 수정 감수자–오역: 원본은 관절이 “제한된 범위내의 미끄러지는 정도의 운동밖에 할 수 없다” 감수자–가독성: 가독성을 위해 수정 감수자–오역: 원본은 평면관절이 수근관절, 족근관절, 천장관절에서 볼 수 있다는 뜻이지 모든 가동관절을 말하는 것이 아님 원어민 에디터-구두점: 미국식 영어에서는 콤마가 “and” 이전에 쓰임 원어민 에디터-명료성: 단위가 쓰이지 않는 경우 1과 9 사이의 숫자는 영어로 쓰여짐 원어민 에디터-명료성: 문장의 시작 혹은 고유명사에만 대문자가 사용될 수 있음

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Glitazone (2,4-thiazolidinedione) compounds including substituted pyridine, pyrimidine, and purine were synthesized based on the crystal structure of Rosiglitazone binding with PPARγ/RXRα to develop new insulin-sensitizing antidiabetic agents. In addition, tyrosine, malonate, and phenyl propionic acid derivatives were synthesized to examine the structure–activity relationships in pharmacophore head groups.

The effects of these compounds were evaluated via the triglyceride accumulation assay using 3T3-L1 cells in vitro. The hypoglycemic and hypolipidemic activities in diabetic KKAy mice were assessed in vivo. Compared with the reference compounds, the substituted pyridine and pyrimidine derivatives in vitro showed excellent activity in general while exhibiting slightly increased toxicity to liver cells. Purine derivatives generally showed lower activity and toxicity to liver cells than the reference compounds.

Most of the selected compounds exhibited better hypoglycemic activity than the references, and the 30 g compound (5-[4-(2-{[6-(4-Methocyphenoxy)pyrimidin-4-yl]methylamino}ethoxy)benzyl]thiazolididione) showed excellent hypolipidemic activity in vivo.

Therefore, the 30 g compound, which is predicted to exert a PPARα/γ dual agonistic effect, was selected as the candidate substance for clinical studies.